Publications

Understanding cancer in the age of single-cell genomics

Lawson D.A. and Kessenbrock, K.

2017

Shahi P, Wang CY, Lawson DA, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z., ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA-3 expression. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3169-3174

2016

Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, March LA, Anderton BN, Rohrbery J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A, PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nature Medicine, Nov;22(11):1321-1329

2015

Lawson D.A., Bhakta N.R., Kessenbrock K., Prummel K., Yu Y., Takai K., Zhou A., Eyob H., Yaswen P., Goga A., Werb Z., Single-cell analysis reveals a stem cell program in human metastatic breast cancer cells. Nature2015, 526(7571):131-5

Sun Z., Lawson D.A., Sinclair E., Wang C., Hetts S.W., Higashida R.T., Dowd C.F., Halbach V.V., Werb Z., Su H., Cooke D.L, Single-cell analysis identifies distinct subpopulations of endothelial cells isolated from human endovascular biopsy tissue. Biotechnology Reports, 2015, 7;157-165

Lawson D.A., Werb Z., Zong Y., Goldstein A.S., Witte O.N., The cleared mammary fat pad transplantation assay for mammary epithelial organogenesis. Review (In press, Cold Spring Harb Protoc)

2013

Kessenbrock K.*, Dijkgraaf G.J.*, Lawson D.A., Littlepage L.E., Shahi P., Pieper U., Werb Z., A novel role for matrix metalloproteinases in the regulation of mammary stem cells via the Wnt signaling pathway. Cell Stem Cell, 2013; 13:300-13

Featured in: “Preview,” Cell Stem Cell. 2013; 13:300; “Research Highlights,” Nat Cell Biol. 2013; 15:1033.

Plaks V.*, Brenot A.*, Lawson D.A., Linnemann J.R., Van Kappel E.C., Wong K.C., de Sauvage F., Klein O.D., Werb Z., LGR5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep., 2013 Jan 31;3(1):70-8.

Selected by Cell Reports as one of six best research reports of 2013

2012

Jiao J., Hindoyan A., Wang S., Tran L.M., Goldstein A.S., Lawson D., Chen D., Li Y., Guo C., Zhang B., Fazli L., Gleave M., Witte O.N., Garraway I.P., Wu H., Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. PLoS One, 2012;7(8):e42564

Littlepage L.E., Adler S.E., Kouros-Mehr H., Huang G., Chou J., Korkola J.E., Lawson D.A., Qu K., Xue Q., Sternlicht M.D., Krig S.R., Dijkgraaf G.J.P., Yaswen P., Collins C.C., Gray J.W., Chang H.W., Werb, Z., The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression, Cancer Discov., 2012 Jul;2(7):638-51

2010

Lukacs R.U., Goldstein A.S., Lawson D.A., Cheng D., Witte O.N., Isolation, cultivation and characterization of adult murine prostate stem cells, Nat Protoc., 2010 Apr;5(4):702-13

2009

Mulholland D., Xin L., Morim A., Lawson D., Witte O.N., Wu H., Lin-Sca-1+CD49fhigh Stem/progenitors are tumor initiating cells in the Pten-null prostate cancer model, Cancer Res, 2009; 69(22):8555-62.

Zong Y., Xin L., Goldstein A.S., Lawson D.A., Teitell M.A., Witte O.N., ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate stem cells, Proc Natl Acad Sci USA, 2009 Jul 28;106(30):12465-70. doi: 10.1073

2008

Lukacs R.U, Lawson D.A., Xin L., Zong Y., Garraway I., Goldstein A.S., Memarzadeh S., Witte O.N., Epithelial stem cells of the prostate and their role in cancer progression, Cold Spring Harb Symp Quant Biol., 2008;73:491-502; Review

Goldstein A., Lawson D.A., Garraway I., Cheng D., Witte O.N., Trop2 identifies prostate stem cells with basal cell characteristics that can differentiate to produce basal, luminal, and neuroendocrine cells in vivo, Proc Natl Acad Sci USA, 2008; Dec 30; 105(52): 20882-7

2007

Lawson D.A. and Witte O.N., Stem cells in prostate cancer initiation and progression, J. Clin. Invest., 2007 Aug; 117(8)2044-50, Review

Xin L., Lukacs R.U., Lawson D.A., Donghui C., Witte O.N., Self-renewal and multilineage differentiation in vitro from murine prostate stem cells, Stem cells, 2007 Nov; 25(11): 2760-9

2006

Xin L., Teitell M.A., Lawson D.A., Kwon A., Mellinghoff I.K., Witte O.N., Progression of prostate cancer by synergy of AKT with genotropic and non-genotropic actions of the androgen receptor, Proc Natl Acad Sci USA, 2006 May 16;103(20):7789-94

Wang S., Garcia A.J., Wu M., Lawson D.A., Witte O.N., Wu H., Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation, Proc Natl Acad Sci USA, 2006 Jan 31;103(5):1480-5

2005

Xin L.*, Lawson D.A.* (co-first author), Witte O.N., The Sca-1 surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis, Proc Natl Acad Sci USA, 2005 May 10; 102(19):6942-7 *equal contribution

Lawson D.A., Xin L., Lukacs R., Xu Q., Cheng D., Witte O.N., Prostate stem cells and prostate cancer, Cold Spring Harbor Symp Quant Biol,, 2005 70:187-96, Review