Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis

I’m so pleased to share our new study out today in Nature Cell Biology where we found that brain resident microglia promote anti-tumor immunity to suppress breast cancer brain metastasis !!

scRNAseq analysis showed that microglia mount a pro-inflammatory response to metastatic infiltration. GEM mice lacking microglia show increased metastasis, decreased survival and reduced natural killer and T cell responses that are critical to suppress tumor outgrowth in the CNS.