2023

Kumar, T., Nee, K., Wei, R. et al. A spatially resolved single-cell genomic atlas of the adult human breast. Nature (2023). https://doi.org/10.1038/s41586-023-06252-9

2021

Lefebvre AEYT, Ma D, Kessenbrock K, Lawson DA, Digman MA. Automated mitochondria segmentation and tracking in live-cell time-lapse images. Nature Methods 2021. https://doi.org/10.1038/s41592-021-01234-z

Ma D, Hernandez GA, Lefebvre AEYT, Alshetaiwi H, Blake K, Dave KR, Rauf M, Williams JW, Davis RT, Evans KT, Longworth A, Masoud MYG, Lee R, Edwards RA, Digman MA, Kessenbrock K, Lawson DA. Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis. Communications Biology 2021;4, 1268. https://doi.org/10.1038/s42003-021-02596-y.

2020

Davis RT, Blake K, Ma D, Ishak Gabra MB, Hernandez GA, Phung AT, Yang Y, Maurer D, Lefebvre AEYT, Alshetaiwi H, Xiao Z, Liu J, Locasale JW, Digman MA, Mjolsness E, Kong M, Werb Z, Lawson DA,* Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing, 2020. Nat. Cell. Biol., Mar;22(3):310-320, *corresponding author

2018

Lawson D.A.*, Kessenbrock K., Davis R.T., Pervalarokis N., Werb Z., Tumor heterogeneity and metastasis at single-cell resolution, 2018. Nat. Cell Biol., Dec;20(12):1349-1360, review, *corresponding author

Nguyen Q.H., Pervolarakis N., Blake K., Ma D., Davis R.T., James J., Phung A.T., Willey E., Kumar R., Jabart E., Driver I., Rock J., Goga A., Khan S.A., Lawson D.A., Werb Z., Kessenbrock K., Profiling human breast epithelial cells using single cell RNA sequencing reveals spectrum of cell diversity, 2018. Nat. Commun., May 23;9(1):2028

Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z, Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers, Genes Dev, 2018 Feb 1; 32(3-4):244-257

2017

Sun Z, Wang CY, Lawson DA, Kwek S, Velozo HG, Owyong M, Lai MD, Fong L, Wilson M, Su H, Werb Z, Cooke DL, Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells, Oncotarget, 2017 Dec 29;9(13):10945-10961

Parker I, Evans KT, Ellefsen K, Lawson DA, Smith IF, Lattice light sheet imaging of membrane nanotubes between human breast cancer cells in culture and in brain metastases. Sci Rep. 2017 Sep 8;7(1):11029

Liu L, Zhang SX, Liao W, Farhoodi HP, Wong CW, Chen CC, Ségaliny AI, Chacko JV, Nguyen LP, Lu M, Polovin G, Pone EJ, Downing TL, Lawson DA, Digman MA, Zhao W., Mechanoresponsive stem cells to target cancer metastases through biophysical cues. Sci Transl Med. 2017 Jul 26;9(400)

Shahi P, Wang CY, Lawson DA, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z., ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA-3 expression. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3169-3174

2016

Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, March LA, Anderton BN, Rohrbery J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A, PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nature Medicine, Nov;22(11):1321-1329

2015

Lawson D.A., Bhakta N.R., Kessenbrock K., Prummel K., Yu Y., Takai K., Zhou A., Eyob H., Yaswen P., Goga A., Werb Z., Single-cell analysis reveals a stem cell program in human metastatic breast cancer cells. Nature, 2015, 526(7571):131-5

Sun Z., Lawson D.A., Sinclair E., Wang C., Hetts S.W., Higashida R.T., Dowd C.F., Halbach V.V., Werb Z., Su H., Cooke D.L, Endovascular biopsy: Strategy for analyzing gene expression profiles of inidividual endothelial cells obtained from human vessels. Biotechnology Reports, 2015, 7;157-165

Lawson D.A., Werb Z., Zong Y., Goldstein A.S., Witte O.N., The cleared mammary fat pad transplantation assay for mammary epithelial organogenesis. Review. Cold Spring Harb Protoc, 2015, Dec 2;2015(12)

2013

Kessenbrock K.*, Dijkgraaf G.J.*, Lawson D.A., Littlepage L.E., Shahi P., Pieper U., Werb Z., A novel role for matrix metalloproteinases in the regulation of mammary stem cells via the Wnt signaling pathway. Cell Stem Cell, 2013; 13:300-13

Featured in: “Preview,” Cell Stem Cell. 2013; 13:300; “Research Highlights,” Nat Cell Biol. 2013; 15:1033.

Plaks V.*, Brenot A.*, Lawson D.A., Linnemann J.R., Van Kappel E.C., Wong K.C., de Sauvage F., Klein O.D., Werb Z., LGR5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep., 2013 Jan 31;3(1):70-8.

Selected by Cell Reports as one of six best research reports of 2013

2012

Jiao J., Hindoyan A., Wang S., Tran L.M., Goldstein A.S., Lawson D., Chen D., Li Y., Guo C., Zhang B., Fazli L., Gleave M., Witte O.N., Garraway I.P., Wu H., Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. PLoS One, 2012;7(8):e42564

Littlepage L.E., Adler S.E., Kouros-Mehr H., Huang G., Chou J., Korkola J.E., Lawson D.A., Qu K., Xue Q., Sternlicht M.D., Krig S.R., Dijkgraaf G.J.P., Yaswen P., Collins C.C., Gray J.W., Chang H.W., Werb, Z., The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression, Cancer Discov., 2012 Jul;2(7):638-51

2010

Lukacs R.U., Goldstein A.S., Lawson D.A., Cheng D., Witte O.N., Isolation, cultivation and characterization of adult murine prostate stem cells, Nat Protoc., 2010 Apr;5(4):702-13

Lawson D.A., Xin L, Goldstein A., Memarzadeh S., Zhong Y., Cheng D., and Witte O.N. 2010. Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc Natl Acad Sci USA 107(6):2610-5. PMC2823887

2009

Mulholland D., Xin L., Morim A., Lawson D., Witte O.N., Wu H., Lin-Sca-1+CD49fhigh Stem/progenitors are tumor initiating cells in the Pten-null prostate cancer model, Cancer Res, 2009; 69(22):8555-62.

Zong Y., Xin L., Goldstein A.S., Lawson D.A., Teitell M.A., Witte O.N., ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate stem cells, Proc Natl Acad Sci USA, 2009 Jul 28;106(30):12465-70. doi: 10.1073

2008

Lukacs R.U, Lawson D.A., Xin L., Zong Y., Garraway I., Goldstein A.S., Memarzadeh S., Witte O.N., Epithelial stem cells of the prostate and their role in cancer progression, Cold Spring Harb Symp Quant Biol., 2008;73:491-502; Review

Goldstein A., Lawson D.A., Garraway I., Cheng D., Witte O.N., Trop2 identifies prostate stem cells with basal cell characteristics that can differentiate to produce basal, luminal, and neuroendocrine cells in vivo, Proc Natl Acad Sci USA, 2008; Dec 30; 105(52): 20882-7

2007

Lawson D.A. and Witte O.N., Stem cells in prostate cancer initiation and progression, J. Clin. Invest., 2007 Aug; 117(8)2044-50, Review

Xin L., Lukacs R.U., Lawson D.A., Donghui C., Witte O.N., Self-renewal and multilineage differentiation in vitro from murine prostate stem cells, Stem cells, 2007 Nov; 25(11): 2760-9

2006

Xin L., Teitell M.A., Lawson D.A., Kwon A., Mellinghoff I.K., Witte O.N., Progression of prostate cancer by synergy of AKT with genotropic and non-genotropic actions of the androgen receptor, Proc Natl Acad Sci USA, 2006 May 16;103(20):7789-94

Wang S., Garcia A.J., Wu M., Lawson D.A., Witte O.N., Wu H., Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation, Proc Natl Acad Sci USA, 2006 Jan 31;103(5):1480-5

2005

Xin L.*, Lawson D.A.* (co-first author), Witte O.N., The Sca-1 surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis, Proc Natl Acad Sci USA, 2005 May 10; 102(19):6942-7 *equal contribution

Lawson D.A., Xin L., Lukacs R., Xu Q., Cheng D., Witte O.N., Prostate stem cells and prostate cancer, Cold Spring Harbor Symp Quant Biol,, 2005 70:187-96, Review